17
2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79364 |
Antiangiogenic agent 4
|
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Antiangiogenic agent 4(Compound 3b)在HFF和HUVEC细胞中抑制Akt磷酸化,可应用于癌症研究。 | |||
T62931 | Antiangiogenic agent 2 | ||
Antiangiogenic agent 2 (compound 3b) 是一种有效的胸苷磷酸化酶 (thymidine phosphorylase) 抑制剂 (IC50: 39.71 μM),表现出抗血管生成作用。 | |||
T72363 |
Antiangiogenic agent 3
|
||
Antiangiogenic agent 3 是一种抗血管生成剂,具有抑制人脐静脉内皮细胞(HUVEC)生长、迁移与趋化运动的作用。此外,该化合物还能降低 Src、cdc42 以及 MAPK 的基因表达。 | |||
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
T1178 |
Temozolomide
NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ |
Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Temozolomide (TMZ) 是一种 DNA 烷基化剂,具有血脑屏障渗透性和口服活性。Temozolomide 具有抗肿瘤活性和抗血管生成活性,还可以诱导细胞凋亡和自噬。 | |||
T1608 |
ADH-1 trifluoroacetate
Exherin trifluoroacetate |
Dehydrogenase | Metabolism |
ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂,具有潜在抗肿瘤和抗血管生成作用。 | |||
T15616 |
JNJ-10198409
3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
JNJ-10198409 是相对选择性的、ATP 竞争性的、具有口服活性的血小板衍生生长因子受体酪氨酸激酶抑制剂,其IC50=2 nM。它对PDGFR-β激酶 (IC50=4.2 nM) 和PDGFR-α激酶 (IC50=45 nM) 有较好的抑制作用。它是双重机制的抗血管生成和肿瘤细胞的抗增殖剂。 | |||
T6695 |
Tasquinimod
他喹莫德,ABR-215050 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Tasquinimod (ABR-215050) 是一种口服抗血管生成剂,有潜在的抗肿瘤活性。它也是 S100A9抑制剂,与 HDAC4Zn2+结合结构域结合的 Kd 值在10到30 nM 之间。 | |||
T70609 |
Bisnafide mesylate
|
||
Bisnafide is a Naphthalimide Analogue that acts as DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent. Antiangiogenic agents can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites. | |||
T25159 |
Bisnafide
DMP 840 |
||
Bisnafide is a Naphthalimide Analogue that acts as a DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent that can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites. | |||
T33281 |
Melflufen
Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1 |
||
Melphalen fluoroaniline, also known as melphalen, J-1, or prodrug J-1, is a prodrug of melphalen, in which the alkylating agent melphalen is combined with fluoroaniline and has potential antitumor and antiangiogenic activities. | |||
T70906 |
EHT-6706
|
||
EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell mon... | |||
T71180 | Oglufanide disodium | ||
Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Check for active clinical trials or closed clinical trials u... | |||
T71204 |
Apatinib HC
Rivoceranib HCl,YN-968D1 HCl |
||
Apatinib, also known as Rivoceranib and YN-968D1, is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. The free-base form is also known as Rivoceranib. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SR... | |||
T9684 |
(Z)-Orantinib
|
||
(Z)-Orantinib ((Z)-SU6668) 是一种有效,选择性,具有口服活性和 ATP 竞争性的 Flk‐1/KDR,PDGFRβ和 FGFR1抑制剂,IC50值分别为 2.1,0.008 和 1.2 μM。(Z)-Orantinib 是有效的抗血管生成和抗肿瘤剂,可诱导已形成的肿瘤消退。 | |||
T70018 |
Apricoxib
|
||
Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related... | |||
T80523 |
Azurin p28 peptide
|
||
Azurin p28 peptide是一种具有肿瘤穿透能力和抗肿瘤活性的肽。它通过与p53结合形成p28:p53复合物,从而降低p53在蛋白酶体中的降解,进而诱导细胞凋亡(apoptosis)或使细胞周期停滞。此外,Azurin p28 peptide通过抑制VEGFR-2、FAK和Akt的磷酸化表现出抗血管生成效果,抑制p53阳性肿瘤的生长。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S2027 |
Rubusoside
|
Others | Others |
Rubusoside 是天然的增溶剂及甜味剂,具有良好的抗血管新生和抗过敏药的特性。 | |||
TMA1743 |
Ergosterol peroxide
|
ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00948 |
Endostatin Protein, Mouse, Recombinant (His)
antiangiogenic agent,type XVIII,collagen α... |
Mouse | HEK293 Cells |
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End... |